As a Mass Effect fan I preordered it and am now 55 hours in with 50% completion. Despite the mixed reviews and some flaws I really like the game and I'm having fun. One reviewer compared it to Dragn Age: Inquisiition in space and I concur.
What I like:
- The graphics are good, there's some beauitful scenery and performance (on high) has been rock solid.
- The story is now shaping up nicely despite a slow start. I now hold the threads to 3 major story elements while also having tons of sidequests which aren't always interesting, but at least they're fleshed out better than the ones in DA:I.
- The combat for me is fun, even though sniper rifles are kinda broken (in SP) as you can kill mobs from afar without alerting even the ones standing next to it.
- The skill system is much more flexible and you can respec, so testing out new skills or just mixing things up so it doesn't become boring is possible. Access to only 3 equipped skills is a bummer though.
- The jetpack is much more than a gimmick, it provides quite a bit of mobility and not only vertically.
- I rather like the sudoku-like puzzles to open the remnant vaults

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What I like less:
- Companions are a little bland, mainly because they don't seem to progress much, unlike Tali or Liara in the original trilogy.
- Some dialogue is really sloppy. There's one quest with an anti AI person, who at the end tells you to thank your AI and there are a few more convos like that.
- The facial animation goes from okay at best to totally weird, mainly because, apart from blinking, the eyes (and eyebrows) hardly animate at all.
- The unskippable transistions when in your ship, while gorgeous, geo old after a while, especially when scanning a planet is just a right click.
Have only played one multiplayer match, but the system is indeed very similar to the one from ME3. Unlike ME3, MP doesn't have an effect on the SP campaign so far. You can send NPCs on missions, like you could in DA:I on the war map and some missions you can do yourself in MP, but that seems to be the extent of it.